BDBM625225 (+)-4,4-difluoro-2-(4-fluorophenyl)-N-[4-(5′-methyl-4′-oxo-3′-phenyl-1′,4′,5′,7′-tetrahydrospiro-[cyclobutane-1,6′-pyrrolo[3,2-c]pyridin]-2′-yl)pyridin-2-yl]butanamide (Enantiomer 2)::US20230322767, Example 51

SMILES CN1C(=O)c2c(CC11CCC1)[nH]c(c2-c1ccccc1)-c1ccnc(NC(=O)C(CC(F)F)c2ccc(F)cc2)c1

InChI Key InChIKey=QWRVRFNSEGHCBL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 625225   

TargetCasein kinase I isoform alpha(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625225(US20230322767, Example 51 | (+)-4,4-difluoro-2-(4-...)
Affinity DataIC50: 1.80nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and full-length human CSNK1A1, expressed by baculovirus infected insect cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetCasein kinase I isoform delta(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625225(US20230322767, Example 51 | (+)-4,4-difluoro-2-(4-...)
Affinity DataIC50: 2.40nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and full-length human CSNK1D, expressed by baculovirus infected insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625225(US20230322767, Example 51 | (+)-4,4-difluoro-2-(4-...)
Affinity DataIC50: 3.20E+3nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent