BDBM625228 (+)-2-(4-fluorophenyl)-N-[4-(5′-methyl-4′-oxo-3′-phenyl-1′,4′,5′,7′-tetrahydrospiro[cyclobutane-1,6′-pyrrolo[3,2-c]pyridin]-2′-yl)pyridin-2-yl]propanamide (Enantiomer 2)::US20230322767, Example 54

SMILES CC(C(=O)Nc1cc(ccn1)-c1[nH]c2CC3(CCC3)N(C)C(=O)c2c1-c1ccccc1)c1ccc(F)cc1

InChI Key InChIKey=CDUQLOKKQHDIFD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 625228   

TargetCasein kinase I isoform alpha(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625228(US20230322767, Example 54 | (+)-2-(4-fluorophenyl)...)
Affinity DataIC50: 1.60nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and full-length human CSNK1A1, expressed by baculovirus infected insect cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetCasein kinase I isoform delta(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625228(US20230322767, Example 54 | (+)-2-(4-fluorophenyl)...)
Affinity DataIC50: 3.60nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and full-length human CSNK1D, expressed by baculovirus infected insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625228(US20230322767, Example 54 | (+)-2-(4-fluorophenyl)...)
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent