BDBM627156 (S)-3-(3-(difluoromethoxy)phenyl)- 1-(5-fluoropyrimidin-2-yl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen-3-yl)- 1H-pyrazolo[4,3-b]pyridine-6- carboxamide::US11787810, Example 3::US20240059700, Example 3

SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1cnc2c(nn(-c3ncc(F)cn3)c2c1)-c1cccc(OC(F)F)c1

InChI Key InChIKey=CSMFWUKVCOOUPB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627156   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627156((S)-3-(3-(difluoromethoxy)phenyl)- 1-(5-fluoropyri...)
Affinity DataIC50: 57nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627156((S)-3-(3-(difluoromethoxy)phenyl)- 1-(5-fluoropyri...)
Affinity DataIC50: 57nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent