BDBM627188 3-[3-(difluoromethoxy)phenyl]-N-[3- (hydroxymethyl)tetrahydrofuran-3- yl]-1-isopropyl-pyrazolo[4,3- b]pyridine-6-carboxamide (faster eluting in OJ-H column, 25% MeOH/CO2)::US11787810, Example 39a::US11787810, Example 39b

SMILES CC(C)n1nc(-c2cccc(OC(F)F)c2)c2ncc(cc12)C(=O)NC1(CO)CCOC1

InChI Key InChIKey=QRDVRGGHUAZWDK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627188   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627188(US11787810, Example 39a | US11787810, Example 39b ...)
Affinity DataIC50: 19nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627188(US11787810, Example 39a | US11787810, Example 39b ...)
Affinity DataIC50: 38nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent