BDBM627195 3-(3-(difluoromethoxy)phenyl)-N-(3- hydroxybutan-2-yl)-1-isopropyl-1H- pyrazolo[4,3-b]pyridme-6- carboxamide (1st faster eluting in AD-H column, 40% MeOH/CO2)::US11787810, Example 45a

SMILES CC(C)Nc1cc(cnc1C(=N)c1cccc(OC(F)F)c1)C(=O)NC(C)C(C)O

InChI Key InChIKey=BASDQMIFAQHBPW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 627195   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627195(3-(3-(difluoromethoxy)phenyl)-N-(3- hydroxybutan-2...)
Affinity DataIC50: 23nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent