BDBM627203 3-(3-(difluoromethoxy)phenyl)-1- isopropyl-N-(3- methyltetrahydrofuran-3-yl)-1H- pyrazolo[4,3-b]pyridine-6- carboxamide (faster eluting in OD-H column, 25% MeOH/CO2)::US11787810, Example 48a::US11787810, Example 48b

SMILES CC(C)Nc1cc(cnc1C(=N)c1cccc(OC(F)F)c1)C(=O)NC1(C)CCOC1

InChI Key InChIKey=WMVOWHWOMAIHMB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627203   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627203(US11787810, Example 48a | US11787810, Example 48b ...)
Affinity DataIC50: 6.30nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627203(US11787810, Example 48a | US11787810, Example 48b ...)
Affinity DataIC50: 16nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent