BDBM627242 3-(3-(difluoromethoxy)phenyl)-1- (3-fluorotetrahydro-2H-pyran-4- yl)-N-(3-methyl-1,1- dioxidothietan-3-yl)-1H- pyrazolo[4,3-b]pyridine-6- carboxamide (slower eluting in IC-H column, 20% MeOH (0.1% DEA)/CO2)::US11787810, Example 75b::US20240059700, Example 75b

SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cnc2c(nn(C3CCOC[C@H]3F)c2c1)-c1cccc(OC(F)F)c1

InChI Key InChIKey=CDAUQJXHHJVCKN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627242   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627242(3-(3-(difluoromethoxy)phenyl)-1- (3-fluorotetrahyd...)
Affinity DataIC50: 9nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627242(3-(3-(difluoromethoxy)phenyl)-1- (3-fluorotetrahyd...)
Affinity DataIC50: 9nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent