BDBM627243 3-(3-(difluoromethoxy)phenyl)- N-(3-methyl-1,1-dioxidothietan- 3-yl)-1-(2- (trifluoromethyl)tetrahydro-2H- pyran-4-yl)-1H-pyrazolo[4,3- b]pyridine-6-carboxamide (faster eluting in AD-H column, 15% EtOH/CO2)::US11787810, Example 76a::US20240059700, Example 76b

SMILES CC1(CS(=O)(=O)C1)NC(=O)c1cnc2c(nn(C3CCO[C@H](C3)C(F)(F)F)c2c1)-c1cccc(OC(F)F)c1

InChI Key InChIKey=TXDFDEXRQYRGTH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627243   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627243(3-(3-(difluoromethoxy)phenyl)- N-(3-methyl-1,1-dio...)
Affinity DataIC50: 21nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627243(3-(3-(difluoromethoxy)phenyl)- N-(3-methyl-1,1-dio...)
Affinity DataIC50: 211nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent