BDBM627256 (S)-3-(3- (difluoromethoxy)phenyl)-4- methyl-N-(3-methyl-1,1- dioxidotetrahydrothiophen-3-yl)- 1-(tetrahydro-2H-pyran-4-yl)-1H- indazole-6-carboxamide::US11787810, Example 84::US20240059700, Example 84

SMILES Cc1cc(cc2n(nc(-c3cccc(OC(F)F)c3)c12)C1CCOCC1)C(=O)N[C@@]1(C)CCS(=O)(=O)C1

InChI Key InChIKey=NYQBQBNLOHWVSN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627256   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627256((S)-3-(3- (difluoromethoxy)phenyl)-4- methyl-N-(3-...)
Affinity DataIC50: 13nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627256((S)-3-(3- (difluoromethoxy)phenyl)-4- methyl-N-(3-...)
Affinity DataIC50: 13nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent