BDBM627268 3-[5-(difluoromethoxy)-3- pyridyl]-1-isopropyl-N-(3- methyl-1,1-dioxo-thietan-3- yl)pyrazolo[4,3-b]pyridine-6- carboxamide::US11787810, Example 95::US20240059700, Example 95

SMILES CC(C)n1nc(-c2cncc(OC(F)F)c2)c2ncc(cc12)C(=O)NC1(C)CS(=O)(=O)C1

InChI Key InChIKey=DKMBSAIHZKUUFW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627268   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627268(3-[5-(difluoromethoxy)-3- pyridyl]-1-isopropyl-N-(...)
Affinity DataIC50: 26nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627268(3-[5-(difluoromethoxy)-3- pyridyl]-1-isopropyl-N-(...)
Affinity DataIC50: 26nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent