BDBM627284 3-(5-cyclobutoxy-2- fluorophenyl)-1-isopropyl-N- (3-methyl-1,1- dioxidothietan-3-yl)-1H- pyrazolo[4,3-b]pyridine-6- carboxamide::US11787810, Example 109::US20240059700, Example 109

SMILES CC(C)n1nc(-c2cc(OC3CCC3)ccc2F)c2ncc(cc12)C(=O)NC1(C)CS(=O)(=O)C1

InChI Key InChIKey=OTLLEXNDYFRWBT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627284   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627284(3-(5-cyclobutoxy-2- fluorophenyl)-1-isopropyl-N- (...)
Affinity DataIC50: 11nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627284(3-(5-cyclobutoxy-2- fluorophenyl)-1-isopropyl-N- (...)
Affinity DataIC50: 11nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent