BDBM627293 3-(2-fluoro-5- (trifluoromethoxy)phenyl)-1- isopropyl-N-(4-methyl-1,1- dioxidotetrahydro-2H- thiopyran-4-yl)-1H- pyrazolo[4,3-b]pyridine-6- carboxamide::US11787810, Example 118::US20240059700, Example 118

SMILES CC(C)n1nc(-c2cc(OC(F)(F)F)ccc2F)c2ncc(cc12)C(=O)NC1(C)CCS(=O)(=O)CC1

InChI Key InChIKey=YHTSXQLKWTWZNI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627293   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627293(3-(2-fluoro-5- (trifluoromethoxy)phenyl)-1- isopro...)
Affinity DataIC50: 20nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627293(3-(2-fluoro-5- (trifluoromethoxy)phenyl)-1- isopro...)
Affinity DataIC50: 20nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent