BDBM627295 3-(2-chloro-5- (difluoromethoxy)phenyl)-1- isopropyl-N-(3-methyl-1,1- dioxidothietan-3-yl)-1H- pyrazolo[4,3-b]pyridine-6- carboxamide::US11787810, Example 120::US20240059700, Example 120

SMILES CC(C)n1nc(-c2cc(OC(F)F)ccc2Cl)c2ncc(cc12)C(=O)NC1(C)CS(=O)(=O)C1

InChI Key InChIKey=HBFSGEDHXYLSTB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627295   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627295(3-(2-chloro-5- (difluoromethoxy)phenyl)-1- isoprop...)
Affinity DataIC50: 7.20nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627295(3-(2-chloro-5- (difluoromethoxy)phenyl)-1- isoprop...)
Affinity DataIC50: 7.20nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent