BDBM627296 3-(2-(2,2-difluoroethoxy)-5- fluoropyridin-4-yl)-1- isopropyl-N-(3-methyl-1,1- dioxidothietan-3-yl)-1H- pyrazolo[4,3-b]pyridine-6- carboxamide::US11787810, Example 121::US20240059700, Example 121

SMILES CC(C)n1nc(-c2cc(OCC(F)F)ncc2F)c2ncc(cc12)C(=O)NC1(C)CS(=O)(=O)C1

InChI Key InChIKey=DNWVWBPAJQEPMW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627296   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627296(3-(2-(2,2-difluoroethoxy)-5- fluoropyridin-4-yl)-1...)
Affinity DataIC50: 8.30nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627296(3-(2-(2,2-difluoroethoxy)-5- fluoropyridin-4-yl)-1...)
Affinity DataIC50: 8.30nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent