BDBM636436 N-[4-(3-anilino-7-ethyl-4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-2-yl)pyridin-2-yl]-4,4-difluoro-2-(4-fluorophenyl)butanamide (Racemate)::US20230365554, Example 5

SMILES CCc1c[nH]c(=O)c2c(Nc3ccccc3)c([nH]c12)-c1ccnc(NC(=O)C(CC(F)F)c2ccc(F)cc2)c1

InChI Key InChIKey=ARCIXQNVMWOXFO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636436   

TargetCasein kinase I isoform delta(Human)
The Broad Institute

US Patent
LigandPNGBDBM636436(N-[4-(3-anilino-7-ethyl-4-oxo-4,5-dihydro-1H-pyrro...)
Affinity DataIC50: 6.40nMAssay Description:CSNK1D-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent

TargetCasein kinase I isoform alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM636436(N-[4-(3-anilino-7-ethyl-4-oxo-4,5-dihydro-1H-pyrro...)
Affinity DataIC50: 7.20nMAssay Description:CSNK1A1-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
The Broad Institute

US Patent
LigandPNGBDBM636436(N-[4-(3-anilino-7-ethyl-4-oxo-4,5-dihydro-1H-pyrro...)
Affinity DataIC50: 7.30E+3nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR (amino acids R669 to A1210), expressed in Sf9 in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent