BDBM636437 N-{4-[3-anilino-5,7-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}-2-(4-fluorophenyl)acetamide (Racemate)::US20230365554, Example 6

SMILES CC1CN(C)C(=O)c2c(Nc3ccccc3)c([nH]c12)-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1

InChI Key InChIKey=DXOCGCLMPFHJFY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636437   

TargetCasein kinase I isoform alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM636437(N-{4-[3-anilino-5,7-dimethyl-4-oxo-4,5,6,7-tetrahy...)
Affinity DataIC50: 2.60nMAssay Description:CSNK1A1-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent

TargetCasein kinase I isoform delta(Human)
The Broad Institute

US Patent
LigandPNGBDBM636437(N-{4-[3-anilino-5,7-dimethyl-4-oxo-4,5,6,7-tetrahy...)
Affinity DataIC50: 6.5nMAssay Description:CSNK1D-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
The Broad Institute

US Patent
LigandPNGBDBM636437(N-{4-[3-anilino-5,7-dimethyl-4-oxo-4,5,6,7-tetrahy...)
Affinity DataIC50: 1.40E+3nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR (amino acids R669 to A1210), expressed in Sf9 in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent