BDBM636440 N-{4-[(7RS)-3-anilino-5,7-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}-2-(4-fluorophenyl)propanamide (Mixture of Stereoisomers)::US20230365554, Example 9

SMILES CC(C(=O)Nc1cc(ccn1)-c1[nH]c2C(C)CN(C)C(=O)c2c1Nc1ccccc1)c1ccc(F)cc1

InChI Key InChIKey=PXIYPQXFGIMIKA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636440   

TargetCasein kinase I isoform alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM636440(N-{4-[(7RS)-3-anilino-5,7-dimethyl-4-oxo-4,5,6,7-t...)
Affinity DataIC50: 5.60nMAssay Description:CSNK1A1-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent

TargetCasein kinase I isoform delta(Human)
The Broad Institute

US Patent
LigandPNGBDBM636440(N-{4-[(7RS)-3-anilino-5,7-dimethyl-4-oxo-4,5,6,7-t...)
Affinity DataIC50: 12nMAssay Description:CSNK1D-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
The Broad Institute

US Patent
LigandPNGBDBM636440(N-{4-[(7RS)-3-anilino-5,7-dimethyl-4-oxo-4,5,6,7-t...)
Affinity DataIC50: 1.30E+4nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR (amino acids R669 to A1210), expressed in Sf9 in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent