BDBM636453 (+)-(2R or S)—N-{4-[cis-3-anilino-4-oxo-1,4,5,5a,6,7,8,8a-octahydrocyclopenta[b]pyrrolo[2,3-d]pyridin-2-yl]pyridin-2-yl}-4,4-difluoro-2-(4-fluorophenyl)butanamide (Enantiomer 1)::US20230365554, Example 22

SMILES FC(F)CC(C(=O)Nc1cc(ccn1)-c1[nH]c2[C@H]3CCC[C@H]3NC(=O)c2c1Nc1ccccc1)c1ccc(F)cc1

InChI Key InChIKey=FAIXFRDVCIWZOZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636453   

TargetCasein kinase I isoform alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM636453((+)-(2R or S)—N-{4-[cis-3-anilino-4-oxo-1,4,5...)
Affinity DataIC50: 5.40nMAssay Description:CSNK1A1-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent

TargetCasein kinase I isoform delta(Human)
The Broad Institute

US Patent
LigandPNGBDBM636453((+)-(2R or S)—N-{4-[cis-3-anilino-4-oxo-1,4,5...)
Affinity DataIC50: 6.30nMAssay Description:CSNK1D-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
The Broad Institute

US Patent
LigandPNGBDBM636453((+)-(2R or S)—N-{4-[cis-3-anilino-4-oxo-1,4,5...)
Affinity DataIC50: 2.00E+4nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR (amino acids R669 to A1210), expressed in Sf9 in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent