BDBM636457 (2S)—N-[4-(3-anilino-5-methyl-4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-2-yl)pyridin-2-yl]-2-(4-fluorophenyl)propanamide (Enantiomer 1)::US20230365554, Example 26

SMILES C[C@H](C(=O)Nc1cc(ccn1)-c1[nH]c2ccn(C)c(=O)c2c1Nc1ccccc1)c1ccc(F)cc1

InChI Key InChIKey=JMADTDZBMULVHU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636457   

TargetCasein kinase I isoform alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM636457((2S)—N-[4-(3-anilino-5-methyl-4-oxo-4,5-dihyd...)
Affinity DataIC50: 5.90nMAssay Description:CSNK1A1-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent

TargetCasein kinase I isoform delta(Human)
The Broad Institute

US Patent
LigandPNGBDBM636457((2S)—N-[4-(3-anilino-5-methyl-4-oxo-4,5-dihyd...)
Affinity DataIC50: 22nMAssay Description:CSNK1D-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
The Broad Institute

US Patent
LigandPNGBDBM636457((2S)—N-[4-(3-anilino-5-methyl-4-oxo-4,5-dihyd...)
Affinity DataIC50: 2.00E+4nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR (amino acids R669 to A1210), expressed in Sf9 in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent