BDBM639870 6,7-Dichloro-9-(3-hydroxypropoxy)-2-methyl-10-(1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one::US20230391786, Example 339

SMILES CN1CCn2c(c(-c3cn[nH]c3)c3c(OCCCO)cc(Cl)c(Cl)c23)C1=O

InChI Key InChIKey=QULQJLAUHQZXMC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 639870   

TargetCyclic GMP-AMP synthase(Human)
Eli Lilly

US Patent
LigandPNGBDBM639870(6,7-Dichloro-9-(3-hydroxypropoxy)-2-methyl-10-(1H-...)
Affinity DataIC50: 7.89nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent