BDBM667820 US11958865, Example 15

SMILES Cc1c2Nc3ncc4c(Cl)nn(CCCOc2nn1-c1cc(F)c(C)nc1C)c4n3

InChI Key InChIKey=VALOPLYOUCEGSA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 667820   

LigandPNGBDBM667820(US11958865, Example 15)
Affinity DataIC50:  1.40nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667820(US11958865, Example 15)
Affinity DataIC50:  0.660nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667820(US11958865, Example 15)
Affinity DataIC50:  4nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent