BDBM676266 US20240166598, Compound XR8-65::US20240166598, Compound XR8-66

SMILES C[C@@H](NC(=O)c1cc(NC2CNC2)ccc1C)c1cccc(c1)-c1ccc(CNC2CCOC2)s1

InChI Key InChIKey=JZRRCGQQCZGHEA-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 676266   

TargetReplicase polyprotein 1a [1564-1878](Severe acute respiratory syndrome coronavirus (SAR...)
University of Arizona

US Patent
LigandPNGBDBM676266(US20240166598, Compound XR8-65 | US20240166598, Co...)
Affinity DataIC50: 330nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 pg/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent

TargetReplicase polyprotein 1a [1564-1878](Severe acute respiratory syndrome coronavirus (SAR...)
University of Arizona

US Patent
LigandPNGBDBM676266(US20240166598, Compound XR8-65 | US20240166598, Co...)
Affinity DataIC50: 620nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 pg/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent

TargetReplicase polyprotein 1a [1564-1878](Severe acute respiratory syndrome coronavirus (SAR...)
University of Arizona

US Patent
LigandPNGBDBM676266(US20240166598, Compound XR8-65 | US20240166598, Co...)
Affinity DataKd:  840nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 pg/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent

TargetReplicase polyprotein 1a [1564-1878](Severe acute respiratory syndrome coronavirus (SAR...)
University of Arizona

US Patent
LigandPNGBDBM676266(US20240166598, Compound XR8-65 | US20240166598, Co...)
Affinity DataKd:  1.53E+3nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 pg/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
US Patent