BDBM699378 US12110276, Compound 72::cyclobuten-1-yl-[3-[4-[(1S)-1,2- dihydroxyethyl]-1-[4- (trifluoromethoxy)phenyl]pyrazolo[3,4- b]pyridin-3-yl]azetidin-1-yl]methanone

SMILES O=C(C1=CCC1)N1CC(c2nn(-c3ccc(OC(F)(F)F)cc3)c3nccc([C@H](O)CO)c23)C1

InChI Key InChIKey=XRRQRUDVKCNHSM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699378   

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 699378BDBM699378(cyclobuten-1-yl-[3-[4-[(1S)-1,2- dihydroxyethyl]-1...)
Affinity DataIC50: 5.60nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 699378BDBM699378(cyclobuten-1-yl-[3-[4-[(1S)-1,2- dihydroxyethyl]-1...)
Affinity DataIC50: 7.5nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 699378BDBM699378(cyclobuten-1-yl-[3-[4-[(1S)-1,2- dihydroxyethyl]-1...)
Affinity DataIC50: 19nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 699378BDBM699378(cyclobuten-1-yl-[3-[4-[(1S)-1,2- dihydroxyethyl]-1...)
Affinity DataIC50: 32nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent