BDBM699388 (3S)-1-[3-[1-(2-fluoroprop-2- enoyl)azetidin-3-yl]-1-[4- (trifluoromethoxy)phenyl]pyrazolo[3,4- b]pyridin-4-yl]-3-hydroxy-pyrrolidin- 2-one::US12110276, Compound 82

SMILES O[C@H]1CCN(C1=O)c1ccnc2n(nc(C3CN(C3)C(=O)C(F)=C)c12)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=RAQDXJIIWQPIQJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699388   

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM699388((3S)-1-[3-[1-(2-fluoroprop-2- enoyl)azetidin-3-yl]...)
Affinity DataIC50: 4.80nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM699388((3S)-1-[3-[1-(2-fluoroprop-2- enoyl)azetidin-3-yl]...)
Affinity DataIC50: 31nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM699388((3S)-1-[3-[1-(2-fluoroprop-2- enoyl)azetidin-3-yl]...)
Affinity DataIC50: 270nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM699388((3S)-1-[3-[1-(2-fluoroprop-2- enoyl)azetidin-3-yl]...)
Affinity DataIC50: 390nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent