BDBM699468 (R,E)-1-(3-(1-(prop-1-en-1- ylsulfonyl)azetidin-3-yl)-1-(4- (trifluoromethoxy)phenyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)ethane-1,2- diol::US12110276, Compound 162

SMILES C\C=C\S(=O)(=O)N1CC(C1)c1nn(-c2ccc(OC(F)(F)F)cc2)c2nccc([C@@H](O)CO)c12

InChI Key InChIKey=GKNRLFKBMBYKNY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699468   

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM699468((R,E)-1-(3-(1-(prop-1-en-1- ylsulfonyl)azetidin-3-...)
Affinity DataIC50: 6.90nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM699468((R,E)-1-(3-(1-(prop-1-en-1- ylsulfonyl)azetidin-3-...)
Affinity DataIC50: 10nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM699468((R,E)-1-(3-(1-(prop-1-en-1- ylsulfonyl)azetidin-3-...)
Affinity DataIC50: 36nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM699468((R,E)-1-(3-(1-(prop-1-en-1- ylsulfonyl)azetidin-3-...)
Affinity DataIC50: 1.00E+3nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent