BDBM70937 US9546164, 100::US9694002, 100

SMILES C[C@H](N1CCC(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CC1)c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=SXOAHIZWCZOILH-HNNXBMFYSA-N

Data  20 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 70937   

LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  4.20nMpH: 7.4 T: 25°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  551nMAssay Description:Inhibition of human Nav1.5/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  552nMpH: 7.4 T: 25°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  4.10nMpH: 7.4 T: 25°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  4.19nMpH: 7.4 T: 25°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  5.80nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  552nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSodium channel protein type 7 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 7 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  16nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 1 hr in presence of veratridine by sodium influx assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 1 hr in presence of veratridine and anthropleurin-C by sodium influx assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 7 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of full length human Nav1.7 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 1 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  202nMAssay Description:Inhibition of full length human Nav1.1 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 2 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  38nMAssay Description:Inhibition of full length human Nav1.2 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 4 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  551nMAssay Description:Inhibition of full length human Nav1.5 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 8 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  198nMAssay Description:Inhibition of human Nav1.6 expressed in CHO cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel subunit beta-2(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  202nMAssay Description:Inhibition of human Nav1.1/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  5.80nMpH: 7.4 T: 25°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In DepthDetails US Patent