BDBM716564 US20250034135, Compound 002

SMILES CC(C)c1ccccc1[C@@H]2CCCN2C%11CC%10(CCN(c9ccc(C(=O)NS(=O)(=O)c5cc([N+](=O)[O-])c(CCC4(F)CCN(C3COC3)CC4)c6[nH]cnc56)c(Oc8cnc7[nH]ccc7c8)c9)CC%10)C%11

InChI Key InChIKey=UYOUWSPUWWOXDA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 716564   

TargetApoptosis regulator Bcl-2 [G101V](Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716564(US20250034135, Compound 002)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 (G101V) and pro-apoptotic protein Bim was performed using Homogeneous Time-R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [D103Y](Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716564(US20250034135, Compound 002)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 (D103Y) and pro-apoptotic protein Bim was performed using Homogeneous Time-R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716564(US20250034135, Compound 002)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 and pro-apoptotic protein Bim was performed using Homogeneous Time-Resolved ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716564(US20250034135, Compound 002)
Affinity DataIC50: 500nMAssay Description:In a white shallow 384-well plate, a total reaction volume was 10 μL. Specifically, it included 2 μL of the compound to be tested (2% DMSO), 4 L His-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716564(US20250034135, Compound 002)
Affinity DataIC50: 2.00E+4nMAssay Description:The inhibitory activity of compounds on human CYP3A4 enzyme was detected using a VIVID™ CYP3A4 GREEN SCRNING KIT reagent kit. The Vivid™ CYP450 scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent