BDBM716819 US20250034135, Compound 257

SMILES COc%10ccc(CN9CCN(C7CC6(CCN(c5cc(Oc2cnc1[nH]ccc1c2)c(C(=O)NS(=O)(=O)c4ccc(NCC3CCOCC3)c([N+](=O)[O-])c4)cn5)CC6)C7)[C@H](c8ccccc8C(C)C)C9)cc%10

InChI Key InChIKey=QVQKJDKQTDVARJ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 716819   

TargetApoptosis regulator Bcl-2 [G101V](Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716819(US20250034135, Compound 257)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 (G101V) and pro-apoptotic protein Bim was performed using Homogeneous Time-R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [D103Y](Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716819(US20250034135, Compound 257)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 (D103Y) and pro-apoptotic protein Bim was performed using Homogeneous Time-R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716819(US20250034135, Compound 257)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 and pro-apoptotic protein Bim was performed using Homogeneous Time-Resolved ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716819(US20250034135, Compound 257)
Affinity DataIC50: 2.00E+4nMAssay Description:The inhibitory activity of compounds on human CYP3A4 enzyme was detected using a VIVID™ CYP3A4 GREEN SCRNING KIT reagent kit. The Vivid™ CYP450 scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent