BDBM716821 US20250034135, Compound 259

SMILES COc%11ccc(CN%10CCN(C8CC7(CCN(c6ccc(C(=O)NS(=O)(=O)c2cc([N+](=O)[O-])c(NC[C@@H]1CC[C@@](C)(O)CC1)c3[nH]cnc23)c(Oc5cnc4[nH]ccc4c5)c6)CC7)C8)[C@H](c9ccccc9C(C)C)C%10)cc%11

InChI Key InChIKey=SLCPECYSHAOYJI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 716821   

TargetApoptosis regulator Bcl-2 [G101V](Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716821(US20250034135, Compound 259)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 (G101V) and pro-apoptotic protein Bim was performed using Homogeneous Time-R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [D103Y](Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716821(US20250034135, Compound 259)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 (D103Y) and pro-apoptotic protein Bim was performed using Homogeneous Time-R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716821(US20250034135, Compound 259)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 and pro-apoptotic protein Bim was performed using Homogeneous Time-Resolved ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716821(US20250034135, Compound 259)
Affinity DataIC50: 2.00E+4nMAssay Description:The inhibitory activity of compounds on human CYP3A4 enzyme was detected using a VIVID™ CYP3A4 GREEN SCRNING KIT reagent kit. The Vivid™ CYP450 scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent