BDBM719730 N-(2-(5-(2-((2- (trifluoromethyl)quinazolin-4- yl)thio)acetyl)thiophen-2- yl)ethyl)pivalamide::US20250051319, Compound 29::US12421222, Compound 29

SMILES CC(C)(C)C(=O)NCCc1ccc(C(=O)CSc2nc(C(F)(F)F)nc3ccccc23)s1

InChI Key InChIKey=NURJZDUCBWYVMA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 719730   

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719730(N-(2-(5-(2-((2- (trifluoromethyl)quinazolin-4- yl)...)
Affinity DataIC50: 100nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/8/2026
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719730(N-(2-(5-(2-((2- (trifluoromethyl)quinazolin-4- yl)...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HDAC enzymes was performed in 384-well plate format using human full-length recombinant HDAC1 and HDAC6, isolated from a baculovirus ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719730(N-(2-(5-(2-((2- (trifluoromethyl)quinazolin-4- yl)...)
Affinity DataIC50: 300nMAssay Description:NanoBRET target engagement was performed against the catalytic domain 2 (CD2) of HDAC6, with minor modifications of kit manufacturer protocol (Promeg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Augustine Therapeutics

US Patent
LigandPNGBDBM719730(N-(2-(5-(2-((2- (trifluoromethyl)quinazolin-4- yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/8/2026
Entry Details
US Patent