BDBM732831 N-[(2-cyanophenyl)methyl]-5-[4,5-difluoro- 2-[(3S)-3-(morpholinomethyl)-3,4-dihydro- 1H-isoquinoline-2-carbonyl]phenyl]-N-(4- hydroxyphenyl)-1,2-dimethyl-pyrrole-3- carboxamide::US20250115577, Compound 53

SMILES Cc1c(C(=O)N(Cc2ccccc2C#N)c2ccc(O)cc2)cc(-c2cc(F)c(F)cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 732831   

TargetApoptosis regulator Bcl-2(Human)
Eil Therapeutics

US Patent
LigandPNGBDBM732831(N-[(2-cyanophenyl)methyl]-5-[4,5-difluoro- 2-[(3S)...)
Affinity DataIC50: 30nMAssay Description:BPS Bioscience, #50222: 3 ng of BCL-2, 5 μL of 1:100 anti-His Tb-labeled donor, 5 μL of 1:100 Dye-labeled acceptor, 5 L of 1:40 BCL-2 Peptide Ligand,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
Eil Therapeutics

US Patent
LigandPNGBDBM732831(N-[(2-cyanophenyl)methyl]-5-[4,5-difluoro- 2-[(3S)...)
Affinity DataIC50: 3.50E+3nMAssay Description:BPS Bioscience, #50223: 10.5 ng of BCL-xL, 5 μL of 1:120 anti-His Tb-labeled donor, 5 μL of 1:120 Dye-labeled acceptor, 5 μL of 1:96 BCL-xL Peptide L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent