BDBM732869 N-(2-carbamoylpyridin-4-yl)-2-(4,4-difluoroazepan-1-yl)-7-methylquinoline-3-carboxamide (KH23)::US20250115578, Example 23

SMILES Cc1ccc2cc(C(=O)Nc3ccnc(C(N)=O)c3)c(N3CCCC(F)(F)CC3)nc2c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 732869   

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732869(N-(2-carbamoylpyridin-4-yl)-2-(4,4-difluoroazepan-...)
Affinity DataIC50: 1.5nMAssay Description:Clamped the cell at −80 mV and then depolarized to 10 mV with a square wave lasting 10 ms to get the Nav1.8 current (see FIG. 1 attached). This proce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent