BDBM732870 N-(2-carbamoylpyridin-4-yl)-2-(4,4-difluoroazepan-1-yl)-6,7-dimethoxyquinoline-3-carboxamide (KH24)::US20250115578, Example 24

SMILES COc1cc2cc(C(=O)Nc3ccnc(C(N)=O)c3)c(N3CCCC(F)(F)CC3)nc2cc1OC

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 732870   

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732870(N-(2-carbamoylpyridin-4-yl)-2-(4,4-difluoroazepan-...)
Affinity DataIC50: 97.1nMAssay Description:Clamped the cell at −80 mV and then depolarized to 10 mV with a square wave lasting 10 ms to get the Nav1.8 current (see FIG. 1 attached). This proce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent