BDBM741214 US20250161307, Example 57

SMILES CC(C)Nc1cc(-c2ccccc2)nc2cc(C(=O)NCCCn3ccnc3)nn12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 741214   

TargetSpermine oxidase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM741214(US20250161307, Example 57)
Affinity DataIC50: 1.76E+5nMAssay Description:Test compounds (75 nL) dissolved in DMSO were added to a 384-well white assay plate (Greiner Bio-one, catalog #784075) using an ECHO Acoustic Dispens...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/19/2025
Entry Details
US Patent

TargetPeroxisomal N(1)-acetyl-spermine/spermidine oxidase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM741214(US20250161307, Example 57)
Affinity DataIC50: 4.44E+6nMAssay Description:The hPAOX assay was run and the data analyzed similarly to the hSMOX assay described above, except the reactions contained 60 pM recombinant PAOX wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/19/2025
Entry Details
US Patent