BDBM8851 3-(4-{4-amino-6-[(4-methylpiperazin-1-yl)methyl]thieno[2,3-d]pyrimidin-5-yl}phenyl)-1-(3-methylphenyl)urea::N-(4-{4-Amino-6-[(4-methylpiperazin-1-yl)methyl]-thieno[2,3-d]pyrimidin-5-yl}phenyl)-N -(3-methylphenyl)urea::Thienopyrimidine deriv. 60

SMILES CN1CCN(Cc2sc3ncnc(N)c3c2-c2ccc(NC(=O)Nc3cccc(C)c3)cc2)CC1

InChI Key InChIKey=PHWICBBDBJYOQR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8851   

TargetVascular endothelial growth factor receptor 2(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8851(N-(4-{4-Amino-6-[(4-methylpiperazin-1-yl)methyl]-t...)
Affinity DataIC50: 589nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8851(N-(4-{4-Amino-6-[(4-methylpiperazin-1-yl)methyl]-t...)
Affinity DataIC50: 590nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2006
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Abbott Laboratories

LigandPNGBDBM8851(N-(4-{4-Amino-6-[(4-methylpiperazin-1-yl)methyl]-t...)
Affinity DataIC50: 630nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2006
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Abbott Laboratories

LigandPNGBDBM8851(N-(4-{4-Amino-6-[(4-methylpiperazin-1-yl)methyl]-t...)
Affinity DataIC50: 631nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8851(N-(4-{4-Amino-6-[(4-methylpiperazin-1-yl)methyl]-t...)
Affinity DataIC50: 794nMAssay Description:Inhibition of cKITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8851(N-(4-{4-Amino-6-[(4-methylpiperazin-1-yl)methyl]-t...)
Affinity DataIC50: 800nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2006
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8851(N-(4-{4-Amino-6-[(4-methylpiperazin-1-yl)methyl]-t...)
Affinity DataIC50: 800nMAssay Description:Inhibition of c-Kit by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed