BDBM50002861 3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid::CHEMBL1071::Daypro::OXAPROZIN::WY-21743::oxaprosin

SMILES OC(=O)CCc1nc(c(o1)-c1ccccc1)-c1ccccc1

InChI Key InChIKey=OFPXSFXSNFPTHF-UHFFFAOYSA-N

Data  2 KI  29 IC50  3 Kd  3 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50002861   

TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetProstaglandin G/H synthase 1(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-lactamase(Escherichia coli (strain K12))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >4.00E+5nMAssay Description:Compound was tested for the inhibition of beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetComplement C5(Human)
Indian Institute of Technology Bhubaneswar

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataKd:  640nMAssay Description:Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  110nMAssay Description:Inhibition of COX2 in LPS-stimulated human monocytes assessed as reduction in PGE2 production by LC-tandem MIS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetBifunctional epoxide hydrolase 2(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of phosphatase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional epoxide hydrolase 2(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  110nMAssay Description:Inhibition of COX2 in LPS-stimulated human monocytes assessed as reduction in PGE2 production by LC-tandem MIS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetBifunctional epoxide hydrolase 2(Mouse)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  3.55E+4nMAssay Description:Inhibition of phosphatase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional epoxide hydrolase 2(Rat)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional epoxide hydrolase 2(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  740nMAssay Description:Inhibition of COX1 in A23187-stimulated human platelets assessed as reduction in TXA2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNuclear receptor subfamily 4 group A member 3(Human)
Ludwig Maximilian University of Munich

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inverse agonist activity at human NOR-1 LBD transiently transfected in HEK293T cells incubated for 16 hrs by Gal4-hybrid reporter gene based Dual-glo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional epoxide hydrolase 2(Rat)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  6.25E+4nMAssay Description:Inhibition of phosphatase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional epoxide hydrolase 2(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of phosphatase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional epoxide hydrolase 2(Rat)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  6.25E+4nMAssay Description:Inhibition of phosphatase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  740nMAssay Description:Inhibition of COX1 in A23187-stimulated human platelets assessed as reduction in TXA2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional epoxide hydrolase 2(Mouse)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional epoxide hydrolase 2(Mouse)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional epoxide hydrolase 2(Rat)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor RXR-alpha(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataEC50:  1.61E+4nMAssay Description:Agonist activity at human RXRalpha transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor RXR-beta(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataEC50:  2.50E+4nMAssay Description:Agonist activity at human RXRbeta transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor RXR-gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataEC50:  4.01E+4nMAssay Description:Agonist activity at human RXRgamma transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNuclear receptor subfamily 4 group A member 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inverse agonist activity at Gal4-fused Nurr1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataKd:  1.00E+6nMAssay Description:Binding affinity to 15N-labelled His6-tagged SARS-CoV Mac3 (527 to 652 residue) expressed in Escherichia coli Rosetta assessed as chemical shift pert...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetUrokinase plasminogen activator surface receptor(Human)
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataKd:  1.14E+5nMAssay Description:Binding affinity to uPAR H47C/N259C (unknown origin) mutant assessed as equilibrium dissociation constant by surface plasmon resonance (SPR) analysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of COX-1 in human plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of COX-2 in IL-1-stimulated human synovial cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetNuclear receptor subfamily 4 group A member 1(Human)
Ludwig Maximilian University of Munich

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inverse agonist activity at human Nur77 LBD transiently transfected in HEK293T cells incubated for 16 hrs by Gal4-hybrid reporter gene based Dual-glo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNuclear receptor subfamily 4 group A member 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inverse agonist activity at human Nurr1 LBD transiently transfected in HEK293T cells incubated for 16 hrs by Gal4-hybrid reporter gene based Dual-glo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMalate dehydrogenase, cytoplasmic(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  1.75E+5nMAssay Description:Inhibition of malate dehydrogenase (MDH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetChymotrypsinogen A(Bovine)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  2.00E+5nMAssay Description:Compound was tested for the inhibition of ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional epoxide hydrolase 2(Mouse)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50002861(3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | CHEM...)
Affinity DataIC50:  3.55E+4nMAssay Description:Inhibition of phosphatase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed