BDBM25391 CHEMBL200622::SB-590885::SB590885::[2-(4-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(pyridin-4-yl)-1H-imidazol-2-yl}phenoxy)ethyl]dimethylamine

SMILES CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2C(CCc2c1)N=O)-c1ccncc1

InChI Key InChIKey=ZLWRKMXLUCZVAR-UHFFFAOYSA-N

Data  5 KI  1 IC50  3 Kd  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 25391   

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of N-terminus His-6 tagged human B-Raf expressed in baculovirus infected insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataKi:  0.160nM ΔG°:  -13.9kcal/molepH: 7.0 T: 37°CAssay Description:BRAF kinase activity was quantified using an ELISA-based MEK phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curve f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataIC50:  290nMAssay Description:Inhibition of b-Raf in human A375 cells assessed phosphorylation of ERKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity at bRaf kinase in fluorescent ligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of B-Raf-mediated Erk phosphorylation in human PREC cells after 60 mins by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of B-Raf-mediated Erk phosphorylation in human HFF cells after 60 mins by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataKd:  0.160nMAssay Description:Binding affinity to human N-His6-tagged B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataKd:  0.300nMpH: 7.5 T: 22°CAssay Description:The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of B-Raf-mediated Erk phosphorylation in human HMEC cells after 60 mins by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)