BDBM4810 (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one::3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-indolin-2-one::CHEMBL276711::SU5146::SU5416::Semaxanib::US10189853, semaxanib::US11111252, Compound SU5416::US9422297, SU5416::cid_5329098
SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1
InChI Key InChIKey=WUWDLXZGHZSWQZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 87 hits for monomerid = 4810
Affinity DataIC50: 8nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 12.9nMAssay Description:RTK inhibitory activity of the compounds 2-12 were evaluated using human tumor cells known to express high levels of EGFR, VEGFR-2 or PDFGR-β us...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISA assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGFR2 in human U251 cells compound pretreated for 60 min before VEGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGF-induced VEGFR2 activation in human U251 cells pretreated for 60 mins followed by VEGF addition and measured after 10 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 1 (VEGFR-1) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 3 [VEGFR-3(Flt-4)] expressed in baculovirusMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Dana-Farber Cancer Institute
Curated by ChEMBL
Dana-Farber Cancer Institute
Curated by ChEMBL
Affinity DataIC50: 68nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 84nMAssay Description:In vitro inhibition of Colony stimulating factor 1 receptor (CSF-1R) expressed in baculovirusMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Milano-Bicocca
Curated by ChEMBL
University of Milano-Bicocca
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Milano-Bicocca
Curated by ChEMBL
University of Milano-Bicocca
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Milano-Bicocca
Curated by ChEMBL
University of Milano-Bicocca
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
TargetPlatelet-derived growth factor receptor alpha(Human)
Institute of Microbial Chemistry (Bikaken)
Curated by ChEMBL
Institute of Microbial Chemistry (Bikaken)
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of PDGFR-alpha (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 220nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 230nMAssay Description:In vitro inhibition of KDRMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Dana-Farber Cancer Institute
Curated by ChEMBL
Dana-Farber Cancer Institute
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of PDGFR-beta (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of Flt4 (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 660nMAssay Description:In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirusMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 700nMpH: 7.5 T: 2°CAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 700nMpH: 7.5 T: 2°CAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 884nMAssay Description:Inhibition of VEGFR induced autophosphorylation of human Vascular endothelial growth factor receptor 2 (VEGFR2) transfected in CHO cellsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDR (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of ALK by ELISA-based kinase assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of ALK using FL-Peptide 13, 5-FAM-KKSRGDYMTMQIG-CONH2 substrate after 60 mins by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Dana-Farber Cancer Institute
Curated by ChEMBL
Dana-Farber Cancer Institute
Curated by ChEMBL
Affinity DataIC50: 2.22E+3nMAssay Description:In vitro inhibition of Platelet-derived growth factor receptor beta expressed in baculovirusMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 2.40E+3nMpH: 7.4 T: 2°CAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of VEGF-induced VEGFR2 autophosphorylation in human U251 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by pho...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of GST-Flt1 kinase domain (unknown origin) expressed in baculovirus infected Sf9 cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:In vitro inhibition of Fibroblast growth factor receptor 1 expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataEC50: 5.00E+3nMAssay Description:For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...More data for this Ligand-Target Pair
Affinity DataIC50: 7.08E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
Affinity DataIC50: 7.08E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Insulin-like growth factor I receptor expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Epidermal growth factor receptor (HER-1,ErbB) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Tyrosine protein kinase receptor TIE-2 (Tek) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of c-SRC kinase expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Fibroblast growth factor receptor expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of c-Abl tyrosine kinase expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Cyclin-dependent kinase 1 (CDK-1) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Met proto-oncogene tyrosine kinase (c-Met) expressed in baculovirusMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Dana-Farber Cancer Institute
Curated by ChEMBL
Dana-Farber Cancer Institute
Curated by ChEMBL
Affinity DataIC50: 1.01E+4nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair