BDBM50531540 CHEBI:75998::GSK-1120212::GSK1120212::JTP 74057::JTP-74057::Mekinist::TMT-212::Tmt212::Trametinib::US11147816, Trametinib::US11701360, Trametinib
SMILES CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
InChI Key InChIKey=LIRYPHYGHXZJBZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50531540
TargetATP-dependent translocase ABCB1(Human)
Rheinische Friedrich-Wilhelms-University of Bonn
Curated by ChEMBL
Rheinische Friedrich-Wilhelms-University of Bonn
Curated by ChEMBL
Affinity DataEC50: 247nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 2.16nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of MEK in human KYSE-520 cells assessed as reduction in p-ERK levelsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of MEK 1/2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 0.920nMAssay Description:Non competitive inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Non competitive inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 0.920nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair