BindingDB PrimarySearch_ki

Found 3 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 1/2' and Ligand = 'BDBM50531540'

Dual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)

IC50: <1nMAssay Description:Inhibition of MEK in human KYSE-520 cells assessed as reduction in p-ERK levelsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Dual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)

IC50: 2nMAssay Description:Inhibition of MEK 1/2 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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PC cid PC sid PDB

Details PubMed PDB

3D Structure (crystal)

Dual specificity mitogen-activated protein kinase kinase 1/2(Homo sapiens (Human))
TBA

Curated by ChEMBL

PNG

BDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)

IC50: 2.16nMAssay Description:TBDMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Purchase MCE
PC cid PC sid PDB

Details US Patent PDB

3D Structure (crystal)