BDBM104089 (Z)-5-(3-Nitro-4-(o-tolylthio)benzylidene)-2-thioxothiazolidin-4-one 23::DNA polymerase inhibitor 23

SMILES Cc1ccccc1Sc1ccc(C=C2SC(S)=NC2=O)cc1[N+]([O-])=O

InChI Key InChIKey=SHKDXDWJERWCHI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 104089   

TargetDNA polymerase lambda(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM104089((Z)-5-(3-Nitro-4-(o-tolylthio)benzylidene)-2-thiox...)
Affinity DataIC50:  3.90E+3nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM104089((Z)-5-(3-Nitro-4-(o-tolylthio)benzylidene)-2-thiox...)
Affinity DataIC50:  1.82E+4nMpH: 7.9Assay Description:Pol β reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.9, 20mM KCl, 5% (v/v) glycerol, 1mM DTT, 2mM MnCl2, 250nM puri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed