BDBM104097 (Z)-5-(2,4-Bis(p-tolylthio)benzylidene)-2-thioxothiazolidin-4-one 31::DNA polymerase inhibitor 31

SMILES Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)c(Sc3ccc(C)cc3)c2)cc1

InChI Key InChIKey=WWHFDWODYCVEBK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 104097   

TargetDNA polymerase lambda(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM104097((Z)-5-(2,4-Bis(p-tolylthio)benzylidene)-2-thioxoth...)
Affinity DataIC50:  4.00E+3nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
University of Konstanz

LigandPNGBDBM104097((Z)-5-(2,4-Bis(p-tolylthio)benzylidene)-2-thioxoth...)
Affinity DataIC50: <5.00E+4nMpH: 7.9Assay Description:Pol β reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.9, 20mM KCl, 5% (v/v) glycerol, 1mM DTT, 2mM MnCl2, 250nM puri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed