BDBM11459 2,6,9-trisubstituted adenine derivative::2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-(cyclopropylmethyl)-9H-purine-2,6-diamine::H622

SMILES N[C@H]1CC[C@@H](CC1)Nc1nc(NCC2CC2)c2ncn(C3CCCC3)c2n1

InChI Key InChIKey=FGLRSCIZYHXTBC-SHTZXODSSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 11459   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Lawrence Berkeley National Laboratory

LigandPNGBDBM11459(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50:  24nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Lawrence Berkeley National Laboratory

LigandPNGBDBM11459(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50:  70nMpH: 8.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 0.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Lawrence Berkeley National Laboratory

LigandPNGBDBM11459(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50:  780nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed