BDBM122533 US8735593, I-1

SMILES Fc1cnc2[nH]nc(Nc3cc(cc(n3)-c3ccccc3Cl)C(F)(F)F)c2c1

InChI Key InChIKey=GBGNHUZQFPYZRM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 122533   

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM122533(US8735593, I-1)
Affinity DataIC50:  50nMpH: 7.5 T: 2°CAssay Description:Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM122533(US8735593, I-1)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...More data for this Ligand-Target Pair
In DepthDetails US Patent