BDBM124076 US10428087, Example 71::US10829502, Example 71::US11401280, Example 71::US8754089, 3-(3-fluorophenyl)-6-methyl-2-((1R)-1-(9H-purin-6-ylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one::US9975907, Example 71
SMILES C[C@@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
InChI Key InChIKey=UAFJYRXPRSODCX-CYBMUJFWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 124076
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataKi: 802nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Incyte Holdings
US Patent
Incyte Holdings
US Patent
Affinity DataIC50: >500nMAssay Description:Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: <50nMAssay Description:Assay A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors w...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Incyte Holdings
US Patent
Incyte Holdings
US Patent
Affinity DataIC50: >500nMAssay Description:PI3Kδ Assay A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: <50nMAssay Description:Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Incyte Holdings
US Patent
Incyte Holdings
US Patent
Affinity DataIC50: >500nMAssay Description:Example A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: <50nMAssay Description:PI3Kα, PI3Kβ, PI3Kγ: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume o...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: <50nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Incyte Holdings
US Patent
Incyte Holdings
US Patent
Affinity DataIC50: >500nMAssay Description:Assay A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL....More data for this Ligand-Target Pair