BDBM13066 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid::CHEMBL139::Diclofenac::US11337935, Compound Diclofenac::US11478464, Compound Diclofenac::US11786535, Compound Diclofenac::{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
SMILES OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
InChI Key InChIKey=DCOPUUMXTXDBNB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 101 hits for monomerid = 13066
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 3.22E+3nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Rattus norvegicus (rat))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 5.10E+3nMAssay Description:Displacement of [3H]NCS-382 from CaMK2alpha in rat brain cerebral cortex membrane homogenates assessed as inhibition constant measured after 60 mins ...More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A9(Homo sapiens (Human))
The University Of British Columbia
Curated by ChEMBL
The University Of British Columbia
Curated by ChEMBL
Affinity DataKi: 1.10E+4nMAssay Description:Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A9More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A7(Homo sapiens (Human))
The University Of British Columbia
Curated by ChEMBL
The University Of British Columbia
Curated by ChEMBL
Affinity DataKi: 1.90E+4nMAssay Description:Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A7More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1-6(Homo sapiens (Human))
The University Of British Columbia
Curated by ChEMBL
The University Of British Columbia
Curated by ChEMBL
Affinity DataKi: 2.30E+4nMAssay Description:Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A6More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A10(Homo sapiens (Human))
The University Of British Columbia
Curated by ChEMBL
The University Of British Columbia
Curated by ChEMBL
Affinity DataKi: 2.80E+4nMAssay Description:Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A10More data for this Ligand-Target Pair
TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 3.54E+4nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by com...More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
The University Of British Columbia
Curated by ChEMBL
The University Of British Columbia
Curated by ChEMBL
Affinity DataKi: 5.20E+4nMAssay Description:Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A1More data for this Ligand-Target Pair
Affinity DataKi: 8.63E+4nM ΔG°: -10.5kcal/moleT: 2°CAssay Description:Briefly, steady-state fluorescence spectra of ANS binding was monitored by measuring the increase in fluorescence signal between 450?550 nm following...More data for this Ligand-Target Pair
Affinity DataKi: 1.60E+5nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.31E+5nMAssay Description:Binding affinity towards human serum albuminMore data for this Ligand-Target Pair
Affinity DataKi: 1.64E+6nMAssay Description:Mechanism based inhibition of human cytochrome P450 3A4 measured by testosterone 6-beta hydroxylationMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A4(Homo sapiens (Human))
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Affinity DataIC50: 1.92E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1-6(Homo sapiens (Human))
The University Of British Columbia
Curated by ChEMBL
The University Of British Columbia
Curated by ChEMBL
Affinity DataIC50: 4.60E+4nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
The University Of British Columbia
Curated by ChEMBL
The University Of British Columbia
Curated by ChEMBL
Affinity DataIC50: 1.55E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of ovine COX1 after 2 mins by EIAMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human recombinant COX2 after 2 mins by EIAMore data for this Ligand-Target Pair
Affinity DataIC50: 6.25E+3nMAssay Description:Inhibition of ovine COX1 peroxidase activity assessed as reduction of PGG2 to PGH2 by measuring oxidized TMPD level by colorimetric assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
K.L.E.U'S College Of Pharmacy
Curated by ChEMBL
K.L.E.U'S College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of ovine COX2 peroxidase activity assessed as reduction of PGG2 to PGH2 by measuring oxidized TMPD level by colorimetric assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human COX1-mediated conversion of arachidonic acid to prostaglandin-E2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human COX1 expressed in sf9 cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of cyclooxygenase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of COX1 assessed as inhibition of arachidonic acid conversion to prostaglandin-E2 releaseMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver estera...More data for this Ligand-Target Pair
Affinity DataIC50: 1.69E+4nMAssay Description:Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver est...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human AR by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of wild-type N-terminal 6-His tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde redu...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of ovine COX1 assessed as inhibition of PGF2alpha production from PGH2 preincubated for 5 mins before arachidonic acid addition measured a...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
K.L.E.U'S College Of Pharmacy
Curated by ChEMBL
K.L.E.U'S College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of ovine COX2 assessed as inhibition of PGF2alpha production from PGH2 preincubated for 5 mins before arachidonic acid addition measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against COX-2 upon incubation for 15 minutes at 37 degree CMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibitory concentration against COX-2; (valus obtained by Kato et al.)More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of human COX2 expressed in sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Inhibition of human recombinant COX-2 assessed as PGF2 alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior...More data for this Ligand-Target Pair
Affinity DataIC50: 610nMAssay Description:Inhibition of ovine COX-1 assessed as PGF2alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior to substrate...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
Institute For Chemical Biology And Center In Molecular Toxicology
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of mouse wild type COX2More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+5nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of COX2 in LPS-stimulated human bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGH2-derived PGF2alpha using arachidonic acid as substrate preincubated for 10 mins followed by sub...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGH2-derived PGF2alpha using arachidonic acid as substrate preincubated for 10 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assayMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 13066
ITC DataΔG°: -8.79kcal/mole −TΔS°: -4.09kcal/mole ΔH°: -4.68kcal/mole logk: 2.80E+6
pH: 7.5 T: 25.00°C
pH: 7.5 T: 25.00°C