BDBM13076 6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide::BMCL182567 Compound 6a::Dichlothiazide::Hydro-D::Hydrochlorothiazide::Hypothiazide::JFD00715::Oretic::cid_3639

SMILES NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl

InChI Key InChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N

Data  59 KI  6 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 13076   

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM13076(6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiad...)
Affinity DataKi:  290nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCarbonic anhydrase 1(Homo sapiens (Human))
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM13076(6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiad...)
Affinity DataKi:  328nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCarbonic anhydrase(Astrosclera willeyana)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM13076(6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiad...)
Affinity DataKi:  394nMAssay Description:Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed