BDBM13418 A313326 Analogue 65::N-(3-chlorophenyl)-5-cyano-2-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl}benzamide

SMILES Cn1cncc1C(OCc1ccc(cc1C(=O)Nc1cccc(Cl)c1)C#N)c1ccc(cc1)C#N

InChI Key InChIKey=DZYGQZQTEVKSFD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 13418   

TargetProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13418(A313326 Analogue 65 | N-(3-chlorophenyl)-5-cyano-2...)
Affinity DataIC50:  0.75nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
The M.S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM13418(A313326 Analogue 65 | N-(3-chlorophenyl)-5-cyano-2...)
Affinity DataIC50:  759nMAssay Description:Inhibition of FTaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Bos taurus (bovine))
Globe Pharmaceutical R and Abbott Laboratories

LigandPNGBDBM13418(A313326 Analogue 65 | N-(3-chlorophenyl)-5-cyano-2...)
Affinity DataIC50:  5.70E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed