BDBM135577 US8846654, 11
SMILES COc1ccc(Cn2c(=O)n(C3CCN(CC3)C=O)c3ccc(OC(CF)CF)cc3c2=O)cc1OC
InChI Key InChIKey=JYHQBYXSPOBQMT-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 135577
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 140nMpH: 7.5Assay Description:By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 39nMpH: 7.5Assay Description:The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...More data for this Ligand-Target Pair