BDBM138348 US8877944, 99

SMILES NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12

InChI Key InChIKey=ARYVAQSYRLZVQD-UHFFFAOYSA-N

Data  61 IC50  6 Kd

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 138348   

TargetPoly [ADP-ribose] polymerase 1(Mus musculus)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd: <10nMAssay Description:The assay is based on the use of a probe of formula (IP) that binds to the NAD binding pocket and takes advantage of the significant change in the po...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  8.60nMAssay Description:Binding affinity to recombinant human HisGST-tagged PARP-1 catalytic domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd: <30nMAssay Description:Binding affinity to full length recombinant human PARP-1 by fluorescence polarization displacement assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  1.39E+3nMAssay Description:Binding affinity to recombinant human HisGST-tagged PARP-2 catalytic domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  9nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM138348(US8877944, 99)
Affinity DataKd:  1.40E+3nMAssay Description:Inhibition of PARP-2 (unknown origin)More data for this Ligand-Target Pair